Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak

作者：Kyleyoung LOW,Layching CHAI,Choonweng LEE,Gan ZHANG,Ruijie ZHANG,Vaezzadeh VAHAB,Chuiwei BONG

摘要：Antibiotics released into the environment through anthropogenic activities exert selective pressure,driving bacteria towards increasing antimicrobial resistance.The prevalence of antibiotics and the ecological risks posed in the riverine estuarine of Larut River and Sangga Besar River,which included wastewater effl uents from hospital,zoo,and poultry slaughterhouse sources were investigated.Solid phase extraction(SPE)followed by high-performance liquid chromatography tandem mass chromatography(HPLC-MS/MS)were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes(sulfonamide,macrolide,fl uoroquinolone,phenicol,trimethoprim,and tetracycline).Sixteen antibiotic residues were detected with concentrations ranging from limit of detection(LOD)to 1262.3 ng/L.Fluoroquinolones and macrolides were the most frequently detected compounds.Erythromycin,clarithromycin,and ofl oxacin detected in hospital and zoo effl uents posed a high risk to algae while tetracycline had low to medium ecological risks toward all the relevant organisms from aquatic environments(algae,invertebrate Daphnia magna,and fi sh).

发文机构：Institute of Ocean and Earth Sciences（IOES） Institute of Graduate Studies Institute of Biological Sciences Guangzhou Institute of Geochemistry School of Marine Sciences

关键词：antibioticresiduesPREVALENCEecologicalriskanthropogenicpollutionRIVERINEESTUARINE

分类号： O62[理学—有机化学]